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The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in older adults with a body mass index (BMI) of greater than 27, provided they also are afflicted by weight-related health concerns such as Tupe2 diabestes, high-cholesterol and/or hypertension (high blood pressure).Contrave is often a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder and as an aid to stop smoking treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination which has a healthy lifestyle that features a reduced-calorie diet and exercise, Contrave provides another treatment option for chronic weight reduction for people who are obese or are overweight and also have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular exercising. Results from a clinical study that enrolled patients without diabetes demonstrated that patients had an average weight loss of four.1% instead of participants who have been given placebos) during a 12- month period, while a different study involving patients with diabetes type 2 symptoms had a typical weight loss of 2% over treatment with placebo at 12 months.

Using two separate drugs to lose weight can be very effective you will find combinations as you're watching FDA now awaiting approval. When dealing with weight loss and the individuals who go through it you should err along the side of caution and allow the FDA do its job and demand some research be done so that the public understands the side effects and risks of the medications before we drive them. Keep in mind that drug companies are in business to generate income and that they would say almost anything to keep people on the medications.

Researchers found that participants using this drug for the year, dropped a few pounds within four weeks and have kept the body weight off during the entire 56 weeks from the study. Contrave is often a combination with the drugs naltrexone and bupropion, which usually reflect a brand new trend of weight-loss drugs which are made up of several active ingredient, which might make them more efficient and safer.

Combo-pilling may be the newest fad or better yet the newest to come under scrutiny and for that reason it is just more publicly known recently, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills is becoming popular could be the fact that by right now there are no long term prescription weight loss supplements that have been licensed by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations are already rejected or have yet to be approved by the FDA.

Seizures certainly are a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug also can raise hypertension and heartrate, and mustn't be used in people who have a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug.

The FDA also warned that Contrave can raise blood pressure levels and heartrate and must stop used in patients with uncontrolled high hypertension, as well as by anyone with heart-related and cerebrovascular (circulation dysfunction impacting the brain) disease. Patients which has a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes having a boxed warning to alert medical professionals and patients towards the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stopping smoking.


'The intent of the bill is usually to give law enforcement and district attorneys a tool to address illicit drug use among expectant women through treatment programs," Tennessee governor Bill Haslam said.